搜索 - 科创

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不光是合成原料药的问题(事实上要生产一种合格的原料药难度也很大)，同样重要的还有剂型以及给药途径，这两者显著影响药物的实际功能，单纯做有机全合成倒是不需要考虑那么多，可以一试

催化剂通过将Cl替换为MsO甲磺酸根，使得Pd中心更加缺电子，制备更加容易，与此同时反应活性也更高，进一步改进的G4催化剂将氨基上一个H替换为甲基，这是专为全合成而设计：G3催化剂会产生与催化剂等量的咔唑，在有机全合成研究中

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