本人单片机小白，在尝试做飞控的途中遇到了一些问题

先看图

目前遇到的问题是ch340G可以与电脑通讯，但尝试写入程序时报错，错误如下

avrdude: stk500_recv(): programmer is not responding

avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0xde

avrdude: stk500_recv(): programmer is not responding

avrdude: stk500_getsync() attempt 2 of 10: not in sync: resp=0xde

avrdude: stk500_recv(): programmer is not responding

avrdude: stk500_getsync() attempt 3 of 10: not in sync: resp=0xde

avrdude: stk500_recv(): programmer is not responding

avrdude: stk500_getsync() attempt 4 of 10: not in sync: resp=0xde

avrdude: stk500_recv(): programmer is not responding

avrdude: stk500_getsync() attempt 5 of 10: not in sync: resp=0xde

avrdude: stk500_recv(): programmer is not responding

avrdude: stk500_getsync() attempt 6 of 10: not in sync: resp=0xde

avrdude: stk500_recv(): programmer is not responding

avrdude: stk500_getsync() attempt 7 of 10: not in sync: resp=0xde

avrdude: stk500_recv(): programmer is not responding

avrdude: stk500_getsync() attempt 8 of 10: not in sync: resp=0xde

avrdude: stk500_recv(): programmer is not responding

avrdude: stk500_getsync() attempt 9 of 10: not in sync: resp=0xde

avrdude: stk500_recv(): programmer is not responding

avrdude: stk500_getsync() attempt 10 of 10: not in sync: resp=0xde

请教一下各位大佬问题出在哪里，谢谢！

ps：pcb确实画的有一些问题，如没有正确差分走线，布线太乱等问题，如果有我没有发现的，也请大家发表高见，谢谢